This story begins with two men, Colton Bane and Kyle Hovey, who work for an evil corporation called Nightrise, waiting outside a theatre in Reno, Nevada. They are waiting to kidnap identical twin brothers Jamie and Scott Tyler, who are part of a magic show in the theatre. Their foster parent, Don White, sells the twins off to them, but Jamie and Scott escape and are pursued. Scott is captured but Jamie is rescued by a woman. He awakens at the woman's house, who introduces herself as Alicia and tells that her son, Daniel, was kidnapped by the same corporation after exhibiting clairvoyant powers. She takes Jamie to his foster parents' house only to realize their murders, and escape only when Jamie uses his telepathic powers.
Alicia and Jamie go to Los Angeles where he reveals his backstory. He then tells her of his previous foster parents and the weird and inexplicable "accidents" associated with them. He tells her about the strange tattoo he has and that he thinks he is an Indian. After these incidents, he and Scott refused to read or control anyone's minds but each other's. They find a lead to one of the men that kidnapped Scott, Colton Banes, and Alicia persuades Jamie to read his mind to find out where Scott is. Jamie manages to find out where Scott is being held: Silent Creek, a juvenile Centre, where he is being tortured in order to be on Nightrise's side.
Alicia decides to seek help from her boss, John Trelawny, who is running for presidency, and manages to convince him about Jamie's powers and to help him get into Silent Creek. Trelawny affirms Jamie's powers and agrees to help him. Jamie is given a false identity and crime and is put into the juvenile Centre to find his brother is there in solitary confinement and Alicia's son Daniel is there too. One night, when he demands that a supervisor named Max Koring take him to his brother, he realizes that his powers do not work in the prison, because of some magnetic field that neutralizes special powers. Koring puts him in solitary confinement for his rudeness and secretly calls Banes to tell him he has found a Gatekeeper.
Jamie does not realize that the second gate was opened. In Peru, Richard and Professor Chambers find Pedro by the helicopter. Pedro tells them that Matt went by himself to stop the gate from opening. Thinking Matt is dead, Richard runs until he finds Matt. Matt "looks like all the life was sucked out of him" and is in a coma. After seeing he has a pulse, Richard runs back to bring get help for Matt.
Feather had examined him earlier and knew about his mysterious tattoo. He explains to Jamie that the twins are two of the Five, but Scott has already left Silent Creek. They work out a convincing plan to save Daniel and escape, whilst at the same time Colton Banes is on their way to Silent Creek. A fight goes on between Feather's tribe and Banes' men, resulting in Jamie being shot in the shoulder and Banes killed by an arrow.
Feather manages to break out with Daniel and Jamie, but Jamie falls unconscious when he is hit by a bullet, and a shaman is called on to bring him back. During this however, Jamie is transported back in time to the height of the war between humanity and the Old Ones ten thousand years ago in England. It becomes clear that the original Gatekeepers are exactly the same as the Gatekeepers in the present, just with different names (except for Matt, who says "I prefer to use my name from your world"). Matt is obviously the leader, and most knowledgeable of the Gatekeepers. He tells Jamie that he sent Sapling to his death on purpose, as the King of the Old Ones would then think he had won, however, should that occur, his counterpart from the future/past would take his place, hence why Jamie was there. Jamie then participates in the battle against the Old Ones, in which the Old Ones are defeated and banished, having mistakenly thought that only four of the Five could come together and letting their guard down. At the place where the Five congregate, a gate is built at the location the Old Ones were banished to, and would be called Raven's Gate by future generations. Jamie sees an eagle which Matt explains is there to take him back.
Jamie's body wakes up in the present and with Feather and Daniel travels back to Reno to reunite Daniel with Alicia, parting ways with Feather afterwards. When he is asleep that night, he is spoken to again by a grey man in the dream world of the Gatekeepers, to kill him.' He finally realized what it means, originally mistaking that Scott was telling him that he was the one going to be killed, but he realizes that Scott is the person going to kill John Trelawny. Throughout the book, Nightrise has always wanted the other candidate, Charles Baker, to become president, who will support the return of the Old Ones. However, when Trelawny became too popular, assassination seemed the only option. It becomes apparent that this will take place during his birthday parade in his home town of Auburn.
Alicia, Danny and Jamie hurry to Auburn to stop the assassination. Jamie sees Scott with Susan Mortlake, a leader of Nightrise, in the crowd, and he tries to send a telepathic message to him, but it fails. Desperate, Jamie commands Warren Cornfeld, Trelawny's bodyguard and would-be assassin (being controlled by Scott), to aim the gun at Susan Mortlake. Cornfield shoots and kills Mortlake, and in chaos Jamie takes Scott and meets up with Alicia and Danny. They meet Natalie Johnson, a member of the Nexus and a friend of Trelawny, who gives them her car to escape. Policemen immediately come after them and the twins bid farewell to Alicia and Danny. Jamie and Scott use a hidden doorway in a cave at Lake Tahoe, and emerge in Cuzco, Peru at the Santo Domingo church. The twins find their way to the Nazca desert and meet with Matt and Pedro, the first and second Gatekeepers.
Meanwhile, Scarlett Adams takes an airplane to Hong Kong to meet her father, who works for Nightrise. As Scarlett is about to go she finds out that John Trelawny has lost the election and that it is suspected that Nightrise has rigged the ballots.